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We recommend that you add folder exclusions for the Continua CI Workspace share folder on the Server machine, and the Agent Workspace folder on the Agent machine.
Continua CI cleans up the Server and Agent Workspace folders periodically, however if adding av folder exclusions for them, we recommend adding scheduled av scans for those folders during quiet periods (typically overnight).
If you are using the bundled Postgresql Database Engine, then you should also add a folder exclusion for C:\ProgramData\VSoft\ContinuaCI\PostgreSQLDB to avoid database errors (av software can cause read timeouts, and issues with backing up the database).
Indexing Services
Windows Indexing Service can cause file locking issues, and the Server and Agent workspace folders should be excluded from the index, or the Index service disabled (it is of limited use in server environments).
Version control clients like TortoiseSVN and TortoiseHG should not be installed on the server or the agent, as these programs do background indexing (for icon overlays) and can also cause file/folder access issues.